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Nerves: (see Deficiency or Essential Fatty Acids)
Nitric Oxide


Nerves
: (see Deficiency or Essential Fatty Acids)
 
Omega-6 fatty acids are key structural components of cell membranes, and are an integral part of the myelin sheath, which protects nerves.
Reference: Present Knowledge in Nutrition, Intl Life Sciences Foundation, July 1990, pp 63., ISBN: 093536840X

An EFA deficiency causes our nervous system to suffer.


Nitric Oxide

Study: "The Effects of Nitric Oxide on Rat Aortic Smooth Muscle in vitro," examined the effects of nitric oxide (NO) and phenylephrine (PHE) on isolated rat aortic rings in smooth muscle bath preparation. PHE (10 -5 M) was initially applied to all tissues to provide a control contractile response. When nitric oxide (10 -5 M) was applied to tissues, relaxation always occurred. When PHE was reapplied after NO had been administered, a contractile response was observed, similar to that of the initial response to PHE. When NO was applied to a tissue that had been pre contracted with PHE, a relaxation of the tissue was observed again. These results indicate that NO has a relaxing effect on aortic tissue, and may play an important role in the management and regulation of blood pressure.
References: Dodd-o, J.M., G. Zheng, H.S. Silverman, E.G. Lakatta and R.C. Ziegelstein. 1997. Endothelium-independent relaxation of aortic rings by the nitric oxide synthase inhibitor diphenyleneiodonium. Br. J. Pharm . (120): 857-864.
Forte, P., M. Copland, L.M. Smith, E. Milne, J. Sutherland, and N. Benjamin. 1997. Basal nitric oxide synthesis in essential hypertension. Lancet 349(9055): 837-842.
Fujimoto, S. and T. Itoh. 1997. Role of nitric oxide and nitric oxide-independent relaxing factor in contraction and relaxation of rabbit blood vessels. Europ. J. Pharm . 330: 177-184.
Griffiths, C., C. Bon, and J. Garthwaite. 1998. Nitric oxide in CNS physiology and pathology. Neurotransmissions 14(1): 3-10.
Huang, Y., C.W. Lau, F.L. Chan, and X.Q. Yao. 1999. Contribution of nitric oxide and K +channel activation to vasorelaxation of isolated rat aorta induced by procaine. Europ. J. Pharm . 367: 231-237.
JMP Statistics and Graphics Guide. Version 3. 1994. SAS Institute Inc., Cary, NC.
Kanagy, N.L., J.R. Charpie, J. Dananberg, and R.C. Webb. 1996. Decreased sensitivity to vasoconstrictors in aortic rings after acute exposure to nitric oxide. Amer. J. Physiol . 271 (Heart Circ. Physiol. 40): H253-H260.
Okawa, T., A.S. Syal, Y.P. Vedernikov, G.R. Saade, K. Chwalisz, R.E. Garfield. 1998. The effects of nitric oxide on the contractility of isolated uterine and aortic rings from pregnant rats. Amer. J. of Ob. and Gyn . 179(3): 721- 726.
Research Biochemicals Incorporated. 1999 Catalog. RBI/Sigma: A member of the Sigma-Aldrich Family of Companies. Natick, MA.
Umans, J.G. 1997. Less nitric oxide, more pressure, or the converse? Lancet 349(9055): 816-817.

Niacin Overdoes Information: http://www.rwjhamilton.org/Atoz/Encyclopedia/article/002509.asp

 

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